Pomaglumetad methionil hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) 是一种选择性 mGlu2/3 受体激动剂 LY404039 的蛋氨酸前药，具有口服活性。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM.LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM.

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) .Animal Model:Male Fischer rats (approximately 250 g) Dosage:3 mg/kg, 10 mg/kg, and 300 mg/kg Administration:Orally; once daily for 7 days Result:Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.

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Neuroscience

GluR

GluR

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635318-26-2

402.87

C12H19ClN2O7S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (62.05 mM; 超声助溶 )

Cl.[H][C@@]12[C@@H](C(O)=O)[C@]1([H])S(=O)(=O)C[C@@]2(NC(=O)[C@@H](N)CCSC)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years